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The use of medicine originated way back from the time of ancient Civilization. Modern drug design is a complex process based on profound understanding of cellular biochemistry, pathology and synthetic chemistry. The current article presents an overview on medicine from antiquity to new age pharmacology. Here, background of development of antibiotics, antibacterial and antiviral agents and HIV-AIDS related drugs is discussed, with special mention of their synthetic procedures as well as mechanism of actions. This article is a tribute to the great scientific minds behind the discovery of highly successful drugs like Sulfonamides, Acyclovir, Retrovir which have been saving millions of lives.

Keywords

Ancient medicines, New age pharmacology, Antibiotics, Sulfonamides, Acyclovir, Retrovir.

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Utilization of Fermentation Process for Production of Two Popular Classes of Antibiotics

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Authors

Santarupa Thakurta ¹, Payel Sen ²

Affiliations
1 Assistant Professor, Department of Chemistry, Prabhu Jagatbandhu College, Andul-Howrah, West Bengal, IN
2 Student, Department of Chemistry, Prabhu Jagatbandhu College, Andul-Howrah, West Bengal, IN

Source

Indian Science Cruiser, Vol 37, No 2 (2023), Pagination: 35-42

Abstract

The gradual resistance to existing antibiotics can be overcome with the use or clinical testing of novel natural products as continuing source of chemical diversity. Often natural products are difficult to be synthesized commercially by chemical methods since their structures are very complex with a number of asymmetric centers. Microbial fermentation remains the only way to isolate wide range of antibiotics. In this article, authors discuss about the production process of two popular classes of antibiotics, cephalosporins and glycopeptides, utilizing fermentation techniques. Yield and quality of the active pharmaceutical ingredient can be improved by using genetically engineered strains and supplying proper nutrition to the fermentation media.

Keywords

Biochemistry.

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